Product Overview
Main Specifications:
- Dihydromyricetin 98% (Liposoluble)
- Dihydromyricetin 30% (Water Soluble)
Dihydromyricetin — commonly abbreviated as DHM and also known by its scientific synonym Ampelopsin — is a naturally occurring flavanonol belonging to the broader family of flavonoid compounds. As one of the most bioactive polyphenols found in traditional botanical sources, DHM has attracted significant attention from the nutraceutical, functional food, and cosmetic industries worldwide.
Vine Tea Extract Dihydromyricetin is derived from the stems and leaves of Ampelopsis grossedentata, a climbing plant native to subtropical regions of southern China. Commonly referred to as vine tea or "Teng Cha," this plant has been used in traditional Chinese herbal medicine for centuries. Modern extraction and purification technologies now allow manufacturers to isolate DHM at exceptionally high purity levels, making it a versatile and commercially valuable ingredient for B2B formulators, brand owners, and dietary supplement manufacturers.
Botanical Source and Raw Material Origin
The raw botanical material used in the production of Vine Tea Extract Dihydromyricetin is Ampelopsis grossedentata, harvested primarily from cultivated and wild-sourced plants in Hunan, Guangxi, and Guizhou provinces of China — regions with well-established traditions of vine tea cultivation and optimal growing conditions for the plant.
Careful sourcing and raw material traceability are foundational to product quality. The plant material undergoes identity verification, moisture assessment, and pesticide residue screening before entering the extraction process. This upstream quality control ensures that only botanically authenticated and contaminant-compliant raw material is used in production.
Extraction and Manufacturing Process
The production of high-purity Vine Tea Extract Dihydromyricetin follows a multi-stage extraction and purification process:
- Pre-treatment — Dried vine tea stems and leaves are cleaned, size-reduced, and prepared for solvent extraction.
- Extraction — Aqueous-ethanol extraction is employed to maximize yield and preserve the integrity of the flavonoid compounds.
- Concentration and Filtration — The crude extract is concentrated under reduced pressure and filtered to remove plant fiber and non-target compounds.
- Recrystallization / Column Chromatography — For high-purity grades (≥98%), the extract undergoes advanced purification using recrystallization or macroporous resin column chromatography to achieve pharmaceutical-grade purity levels.
- Drying and Milling — The purified material is spray-dried or vacuum-dried and milled to a uniform powder.
- In-Process QC Testing — HPLC analysis is performed at multiple stages to verify active compound concentration and detect any off-specification batches.
This GMP-compliant manufacturing process ensures consistent potency, batch-to-batch reproducibility, and compliance with international quality standards.
Active Compound and Chemical Profile
| Property | Details |
|---|---|
| Common Name | Dihydromyricetin (DHM) |
| Synonym | Ampelopsin |
| Chemical Class | Flavanonol (Dihydroflavonol) |
| Molecular Formula | C₁₅H₁₂O₈ |
| Molecular Weight | 320.25 g/mol |
| CAS Number | 27200-12-0 |
| Appearance | Pale Yellow Powder |
| Odor | Characteristic |
| Solubility | Available in liposoluble (98%) and water-soluble (30%) formats |
The availability of both a liposoluble high-purity form (98%) and a water-soluble standardized form (30%) provides formulation flexibility across a wide range of product types. The water-soluble variant is particularly well suited for beverage applications, effervescent tablets, and hydrophilic capsule formulations, while the liposoluble grade integrates readily into oil-based delivery systems, softgels, and lipid-based nutraceutical matrices.
Certificate of Analysis (Representative Batch)
| Item | Specification | Test Method | Result |
|---|---|---|---|
| Physical Properties | |||
| Appearance | Pale Yellow Powder | Organoleptic | Conforms |
| Odor | Characteristic | Organoleptic | Conforms |
| Loss on Drying | ≤1.0% | USP37 \<921> | 0.12% |
| Ignition Ash | ≤1.0% | USP37 \<561> | 0.08% |
| Active Ingredient | |||
| Dihydromyricetin | ≥98% | HPLC | 99.20% |
| Heavy Metals | |||
| Lead (Pb) | ≤3.0 mg/kg | USP37 \<233> | Conforms |
| Arsenic (As) | ≤2.0 mg/kg | USP37 \<233> | Conforms |
| Cadmium (Cd) | ≤1.0 mg/kg | USP37 \<233> | Conforms |
| Mercury (Hg) | ≤0.1 mg/kg | USP37 \<233> | Conforms |
| Microbiological | |||
| Total Plate Count | ≤1000 cfu/g | USP30 \<61> | 200 cfu/g |
| Yeast & Mold | ≤100 cfu/g | USP30 \<61> | 10 cfu/g |
| E. Coli | Negative | USP30 \<62> | Conforms |
| Salmonella | Negative | USP30 \<62> | Conforms |
Full certificates of analysis are available upon request for each production batch. Third-party testing reports can also be provided to support regulatory submissions and customer quality audits.
Functional Benefits and Bioactivity
Vine Tea Extract Dihydromyricetin is one of the most comprehensively studied flavonoid compounds in the nutraceutical space. Key functional attributes supported by scientific literature and industry research include:
Antioxidant Activity
DHM demonstrates potent free radical scavenging capacity, with activity levels that compare favorably against well-established antioxidants such as quercetin and rutin. Its hydroxyl group configuration is central to its ability to neutralize reactive oxygen species (ROS) and reduce oxidative stress at the cellular level.
Liver Protection and Hepatoprotective Function
One of the most recognized applications of DHM is its hepatoprotective effect. Research indicates that DHM supports liver cell integrity, promotes liver enzyme normalization, and helps protect against liver damage induced by oxidative stress and toxic compounds. This makes it a high-demand ingredient in liver support dietary supplements.
Alcohol Metabolism and Anti-Intoxication Support
DHM has been widely studied for its ability to accelerate alcohol metabolism by enhancing the activity of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). These enzymatic pathways are critical for converting ethanol and acetaldehyde into non-toxic metabolites, which is why DHM is a leading ingredient in hangover recovery products and alcohol metabolism support supplements.
Anti-Inflammatory Properties
DHM exhibits meaningful anti-inflammatory activity by modulating key inflammatory signaling pathways. This property broadens its applicability in formulations targeting metabolic wellness, immune support, and general anti-aging nutrition.
Blood Sugar and Lipid Regulation
Emerging research highlights DHM's potential role in supporting healthy blood glucose and blood lipid levels, areas of growing interest in metabolic health formulation. These bioactivities make DHM relevant to products targeting weight management, cardiovascular wellness, and diabetes-supportive supplementation categories.
Skin Care and Cosmetic Applications
The antioxidant and anti-inflammatory properties of Vine Tea Extract Dihydromyricetin have made it an increasingly popular active ingredient in functional skin care formulations, including anti-aging serums, brightening creams, and protective topical products.
Industry Applications
Vine Tea Extract Dihydromyricetin serves as a multifunctional ingredient across several high-growth industries:
- Dietary Supplements — Liver support capsules, hangover recovery formulas, antioxidant blends, metabolic health supplements
- Functional Beverages — Alcohol metabolism drinks, liver wellness tonics, sports recovery beverages (water-soluble grade preferred)
- Nutraceutical Raw Materials — Bulk ingredient supply for contract manufacturers and private label brands
- Cosmetics and Skin Care — Anti-aging formulas, antioxidant serums, protective topical products
- Food and Health Products — Functional food enrichment, health tea blends, and botanical wellness products
Formulation Compatibility and Stability
- pH Stability: DHM demonstrates reasonable stability across a moderate pH range; formulations should be optimized for the intended delivery format.
- Light and Heat Sensitivity: As with most polyphenolic compounds, exposure to prolonged direct sunlight and high temperatures should be minimized during processing and storage.
- Compatibility: Compatible with a broad range of excipients, active ingredients, and delivery systems including capsules, tablets, softgels, powders, and liquid formats. The water-soluble grade is specifically engineered for aqueous-based applications.
Quality Standards and Certifications
All products manufactured by Extract Makers are produced in a fully certified GMP-standard facility. The facility and product portfolio are supported by the following internationally recognized quality credentials:
- ✅ GMP (Good Manufacturing Practice)
- ✅ HACCP (Hazard Analysis and Critical Control Points)
- ✅ ISO 22000 (Food Safety Management)
- ✅ ISO 9001 (Quality Management Systems)
- ✅ Kosher Certified
- ✅ Halal Certified
- ✅ FDA Facility Registration
These certifications demonstrate our commitment to consistent product quality, food safety compliance, and international regulatory standards — essential for importers, brand owners, and distributors supplying regulated markets in North America, Europe, and Asia-Pacific.
Packaging Specifications
Standard packaging options are available to accommodate orders of all sizes:
| Order Volume | Packaging Format |
|---|---|
| Small / Sample Orders | Sealed aluminum foil bags (1 kg – 5 kg) |
| Mid-Size Orders | Double-lined carton boxes (10 kg – 20 kg) |
| Large / Bulk Orders | Fiber drums with inner liner (10 kg – 30 kg) |
Private Label and Custom Packaging
Extract Makers offers comprehensive private label services for brand owners and distributors. We can customize packaging with your brand logo, label design, and product specifications, enabling you to bring retail-ready products to market efficiently — eliminating the need for in-house repackaging operations and significantly reducing your time to market.
Storage Recommendations
- Store in a cool, dry, well-ventilated area away from direct sunlight and heat sources.
- Recommended storage temperature: below 25°C
- Keep containers tightly sealed when not in use to prevent moisture absorption and oxidative degradation.
- Shelf Life: 24 months (2 years) from the date of manufacture when stored under recommended conditions.
Shipping Options
Extract Makers supports efficient global logistics for customers across all major markets:
- Express Shipping (Orders Below 1 Ton): DHL, FedEx, UPS, EMS, and other international courier services
- Railway Freight: Available for select destinations, offering a cost-effective alternative for mid-volume orders
- Sea Freight: Available for large-volume bulk orders where ocean shipping is accessible and economical
All shipments are accompanied by a full documentation package including Certificate of Analysis, Material Safety Data Sheet (MSDS), and relevant compliance documents to facilitate smooth customs clearance.
Free Samples Available
We understand that quality verification is a critical part of the procurement process. Extract Makers provides complimentary samples of 10g–20g for qualified buyers to evaluate product quality prior to placing bulk orders. For high-value or premium-grade products, sample availability and pricing will be confirmed on a case-by-case basis.
To request a free sample or obtain a product quotation, please contact us directly at: [email protected]
After-Sales Support and Quality Guarantee
Our commitment to customer satisfaction extends beyond the point of sale. All products carry a 2-year quality guarantee within their stated shelf life. In the event that a product fails to meet the agreed specifications, our hassle-free return and refund policy ensures resolution based on the quantity of non-conforming goods returned.
Our dedicated technical and customer service team is available to assist with:
- Formulation recommendations and ingredient compatibility guidance
- Regulatory documentation support
- Custom specification development
- Reorder management and supply chain planning
Why Source Vine Tea Extract Dihydromyricetin from Extract Makers?
- High-Purity Grades Available: 98% liposoluble and 30% water-soluble formulations to meet diverse application requirements
- Verified Botanical Source: Traceable raw material from authenticated Ampelopsis grossedentata cultivation regions
- Rigorous Quality Testing: HPLC-verified potency, heavy metals testing, and full microbiological screening on every batch
- Global Compliance Certifications: GMP, HACCP, ISO 22000, ISO 9001, Kosher, Halal, and FDA registration
- Flexible MOQ and Packaging: Scalable order quantities with private label options available
- Reliable Supply Chain: Consistent production capacity with efficient global shipping support
- Responsive Technical Support: Expert assistance throughout the sourcing, formulation, and regulatory process
Contact Us
For bulk pricing, sample requests, custom specifications, or any product inquiries regarding Vine Tea Extract Dihydromyricetin, please reach out to our team:
📧 Email: [email protected]
Note: Extract Makers maintains a product catalog of over 2,000 botanical extracts, nutraceutical ingredients, food additives, and specialty raw materials. If a specific product or specification is not listed on our website, please contact us directly — our team will source or confirm availability promptly.
