Andrographis paniculata Extract

Product Overview

Andrographis paniculata extract is a premium botanical ingredient derived from the whole plant of Andrographis paniculata (Burm.F.) Nees, a medicinal herb widely recognized in traditional Ayurvedic and Chinese medicine systems. At Extract Makers, we supply this high-quality phytochemical ingredient in bulk quantities to manufacturers, formulators, distributors, and brand owners across the nutraceutical, pharmaceutical, functional food, and cosmetic sectors.

Basic Product Specifications

Botanical Source & Raw Material Background

Andrographis paniculata is an annual herbaceous plant native to South Asian countries, including India, Sri Lanka, and widely cultivated across Southeast Asia including Thailand, China, and Indonesia. Known colloquially as "King of Bitters" due to its intensely bitter taste, this plant has been a cornerstone of traditional medicine for centuries, particularly in Ayurveda and Traditional Chinese Medicine (TCM), where it has been used to address a broad range of health conditions including fever, infections, and inflammatory disorders.

The raw material used in Extract Makers' Andrographis paniculata extract is sourced from traceable, controlled cultivation regions to ensure botanical authenticity, consistent phytochemical profiles, and compliance with international quality standards. Careful selection at the raw material stage is fundamental to producing a finished extract with reliable bioactive content and batch-to-batch consistency.

Extraction & Manufacturing Process

The manufacturing of Andrographis paniculata extract involves a multi-stage extraction and purification process designed to concentrate the key bioactive compounds while minimizing impurities. The general process includes:

• Harvesting & Pre-processing: Aerial parts of the plant are harvested at optimal maturity to maximize andrographolide content, followed by drying and size reduction.
• Solvent Extraction: Controlled solvent extraction techniques are employed to selectively isolate the active phytochemicals from the plant matrix.
• Purification & Concentration: The crude extract undergoes purification steps to achieve the target specification and remove undesirable residues.
• Drying & Micronization: The purified extract is spray-dried or vacuum-dried to produce a fine, uniform powder with excellent flowability.
• Quality Control & Testing: Each batch is tested using HPLC to verify the concentration of andrographolide and related compounds, ensuring compliance with the specified potency.

This rigorous production process is managed under GMP-compliant manufacturing conditions, supporting the high standards expected by international buyers.

Active Phytochemical Constituents

The pharmacological profile of Andrographis paniculata extract is primarily attributed to a class of bioactive compounds known as diterpenoid lactones. The principal active constituents include:

• Andrographolide — The most abundant and pharmacologically significant compound, extensively studied for its anti-inflammatory, antiviral, and anticancer properties.
• Dehydroandrographolide — A structurally related compound with documented immunomodulatory activity.
• Deoxyandrographolide — Known for its contribution to the antimicrobial and anti-inflammatory profile of the extract.
• Neoandrographolide — Associated with hepatoprotective and anti-inflammatory effects.

The standardized extract supplied by Extract Makers delivers consistent levels of these bioactive constituents, with andrographolide being the primary marker compound quantified via HPLC testing. Custom standardization levels are available based on customer formulation requirements.

Functional Benefits & Pharmacological Activity

Scientific research and traditional usage have identified a broad spectrum of functional properties associated with Andrographis paniculata extract, making it a versatile active ingredient for multiple product categories:

Anti-Inflammatory & Immunomodulatory Activity

Andrographolide has been extensively studied for its capacity to modulate inflammatory pathways, including NF-κB signaling, and to support immune system regulation. This makes the extract a sought-after ingredient in immune health formulations, particularly for seasonal wellness and respiratory support products.

Anticancer Research Applications

Preclinical studies have demonstrated that andrographolide treatment can inhibit the proliferation of multiple tumor cell lines across various cancer types. Research has shown that andrographolide modulates key cellular processes and molecular targets, resulting in increased cytotoxic activity of lymphocytes against cancer cells, suggesting a potential indirect anticancer mechanism. These findings continue to drive interest in Andrographis paniculata extract as a research-stage bioactive ingredient.

Antimicrobial & Antibacterial Properties

The extract exhibits notable activity against a range of bacterial strains, supporting its use in formulations designed for infection prevention, oral health, and gut microbiome support.

Blood Sugar Management

Andrographis paniculata extract has been studied for its potential role in supporting healthy blood glucose levels, making it relevant to formulators targeting metabolic health, diabetes management support, and weight management product lines.

Digestive Health Support

Traditionally used as an anthelmintic agent, the extract supports intestinal health by helping to address intestinal parasites and promoting gastrointestinal wellness.

Acne & Skin Health Applications

Due to its anti-inflammatory and antimicrobial characteristics, Andrographis paniculata extract is increasingly incorporated into dermatological and cosmetic formulations targeting acne-prone skin, blemish control, and skin-soothing products.

Industry Applications

Andrographis paniculata extract is a multifunctional ingredient applicable across a diverse range of industries and product formats:

• Nutraceuticals & Dietary Supplements: Capsules, tablets, softgels, powdered drink mixes, and functional blends targeting immune support, anti-inflammatory wellness, and metabolic health.
• Pharmaceutical & OTC Products: Herbal medicinal products, standardized botanical APIs, and research-stage pharmaceutical compounds.
• Functional Food & Beverages: Health drinks, fortified foods, herbal teas, and wellness shots where botanical actives are valued.
• Cosmetics & Personal Care: Topical formulations including serums, creams, and acne-treatment products leveraging the extract's skin-active properties.
• Animal Nutrition: Incorporation into veterinary supplements and animal feed additives to support animal health and immune function.

Physical & Chemical Properties

• Form: Fine powder
• Color: Light yellow to off-white
• Odor: Characteristic, slightly bitter
• Taste: Intensely bitter (characteristic of andrographolide content)
• Particle Size: Micronized for improved dispersibility
• Moisture Content: Controlled to meet standard specifications
• Heavy Metals: Tested and compliant with international limits
• Microbial Limits: Meets food and pharmaceutical grade microbiological standards

Solubility & Stability

Andrographis paniculata extract demonstrates partial solubility in water and good solubility in ethanol and other polar organic solvents. For aqueous-based formulations, the use of appropriate solubilization techniques or co-solvents is recommended to achieve optimal dispersion.

In terms of stability, the extract is best maintained when protected from direct light, moisture, and elevated temperatures. Under proper storage conditions, the bioactive constituents — particularly andrographolide — remain stable throughout the product's shelf life.

Storage Recommendations

To preserve the quality, potency, and shelf life of Andrographis paniculata extract, the following storage conditions are recommended:

• Store in a cool, dry, and well-ventilated area
• Keep away from direct sunlight and heat sources
• Maintain storage temperature at below 25°C with relative humidity below 60%
• Ensure containers are tightly sealed after each use
• Keep away from incompatible materials and strong oxidizing agents

Under these conditions, the product maintains its specified quality for the duration of the stated shelf life.

Packaging Specifications

Extract Makers supplies Andrographis paniculata extract in packaging formats suited to bulk B2B procurement requirements:

• Standard packaging: 25 kg/drum (fiber drum with double polyethylene inner lining)
• Custom packaging: Available upon request for smaller or larger bulk quantities
• Sample packaging: Kilogram-scale samples available for evaluation and formulation trials

All packaging is designed to protect the product integrity during international shipping and long-term storage, in compliance with relevant export standards.

Quality Standards & Certifications

Extract Makers operates under a comprehensive quality management framework to ensure the consistency, purity, and safety of every batch of Andrographis paniculata extract supplied. Our quality assurance program includes:

• GMP-compliant manufacturing facilities
• HPLC-based standardization for andrographolide and key bioactive compounds
• Heavy metal testing (Pb, As, Cd, Hg)
• Microbiological testing (Total plate count, yeast & mold, E. coli, Salmonella)
• Pesticide residue screening in compliance with international standards
• Batch-specific Certificate of Analysis (CoA) provided with every shipment
• Third-party testing available upon request
• Available with supporting documentation for ISO, Kosher, Halal, and Organic certification requirements depending on specification

Why Source Andrographis Paniculata Extract from Extract Makers?

Extract Makers is a professional bulk supplier specializing in plant-derived extracts, fungal ingredients, and botanical actives for the nutraceutical, pharmaceutical, food and beverage, cosmetic, and animal nutrition industries. Our capabilities include:

• Customized specifications: We can adjust extraction ratios, standardization levels, and powder or liquid formats to meet your exact formulation requirements.
• Scalable bulk supply: From kilogram-scale samples to multi-ton commercial orders, we maintain reliable supply chain capacity.
• Consistent quality: Rigorous raw material sourcing, controlled manufacturing processes, and comprehensive testing protocols ensure batch-to-batch consistency.
• Technical support: Our team of botanical extract specialists is available to assist with formulation guidance, regulatory documentation, and product development.
• Competitive pricing: Direct manufacturer supply model enables cost-effective pricing for distributors, brand owners, and private label customers.
• Transparent traceability: From field to finished extract, our supply chain documentation supports the traceability requirements of international buyers.

Request a Quote or Sample

If you are a supplement manufacturer, pharmaceutical company, cosmetic brand, contract manufacturer, or bulk ingredient distributor looking to source high-quality Andrographis paniculata extract at competitive bulk pricing, we welcome your inquiry.

Contact our sales team at [email protected] to request a product sample, Certificate of Analysis, technical data sheet, or customized bulk quotation. Our team is prepared to support your sourcing needs with professional, responsive service.

Sarah