Sodium Hyaluronate Powder is one of the most sought-after bioactive ingredients in the global personal care, nutraceutical, and pharmaceutical raw material markets. As the sodium salt form of hyaluronic acid, it offers superior water solubility, biological compatibility, and formulation versatility compared to pure hyaluronic acid — making it the preferred grade for commercial and industrial applications worldwide.
At Extract Makers, we supply pharmaceutical-grade, cosmetic-grade, and food-grade Sodium Hyaluronate Powder in bulk quantities, backed by rigorous quality control, internationally recognized certifications, and flexible logistics solutions for global buyers.
What Is Sodium Hyaluronate Powder?
Sodium Hyaluronate is the sodium salt derivative of hyaluronic acid (also referred to as hyaluronan). Chemically, it is classified as an anionic, non-sulfated glycosaminoglycan — a type of long-chain polysaccharide that occurs naturally within the human body. It is found in particularly high concentrations in the synovial fluid of joints, the vitreous humor of the eyes, and the extracellular matrix of skin tissue.
Why Sodium Hyaluronate Instead of Pure Hyaluronic Acid?
While the two compounds are closely related, their practical usability differs significantly. Pure hyaluronic acid has a pH range of approximately 2.5 to 5.0, making it highly acidic and incompatible with most food, beverage, and cosmetic formulations. Sodium Hyaluronate, by contrast, has a pH range of 5.0 to 8.5, which aligns well with the physiological pH of human skin and mucous membranes. This neutralized form is substantially more stable in aqueous environments, more bioavailable upon topical or oral delivery, and far more practical for use across diverse product categories. As a result, pure hyaluronic acid is rarely utilized in finished commercial products, while Sodium Hyaluronate has become the industry standard ingredient.
Physical and Chemical Properties
Sodium Hyaluronate Powder is a white to off-white, odorless, fine powder. It is freely soluble in water, forming clear to slightly opalescent viscous solutions depending on concentration and molecular weight. It is insoluble in most organic solvents including ethanol, acetone, and ether.
Key physicochemical characteristics include:
- Appearance: White powder
- pH (0.5% aqueous solution, 25°C): 5.0 – 8.5
- Solubility: Freely soluble in water; insoluble in organic solvents
- Hygroscopicity: High — absorbs and retains moisture effectively
- Molecular weight range: Available from below 5,000 Dalton up to above 2,000,000 Dalton
- Viscosity: Varies significantly with molecular weight grade
The molecular weight of Sodium Hyaluronate is one of its most critical parameters, as it directly determines the ingredient's functionality, penetration depth, and application suitability. Higher molecular weight grades are preferred for film-forming and surface moisturization, while low and ultra-low molecular weight fractions are used for deep skin penetration, oral bioavailability, and ophthalmic applications.
Sodium Hyaluronate Molecular Weight Grades
Extract Makers supplies Sodium Hyaluronate Powder across a comprehensive range of molecular weight specifications to serve the full breadth of formulation requirements:
| Molecular Weight | Primary Applications |
|---|---|
| < 5,000 Dalton | Cosmetic, Food Grade |
Buyers are encouraged to specify the required molecular weight range at the time of inquiry to ensure the most appropriate grade is supplied for the intended application. Our technical team is available to assist with grade selection based on formulation type and performance requirements.
Functional Benefits of Sodium Hyaluronate Powder
Sodium Hyaluronate is valued across multiple industries for its outstanding biological and physicochemical properties. Key functional benefits include:
Superior Moisture Retention
Sodium Hyaluronate is renowned for its exceptional hygroscopic capacity. A single gram of high-molecular-weight Sodium Hyaluronate can bind up to approximately six liters of water under physiological conditions. This makes it an unparalleled humectant in skincare, wound care, and ophthalmic formulations.
Anti-Inflammatory and Tissue-Protective Activity
Research supports the role of Sodium Hyaluronate in modulating inflammatory responses at tissue interfaces. It plays a structural and signaling role within the extracellular matrix, contributing to reduced inflammation in joint tissues, ocular surfaces, and skin.
Skin Health Promotion
In topical formulations, Sodium Hyaluronate improves skin hydration, smoothness, elasticity, and barrier function. It supports the visible reduction of fine lines and wrinkles associated with skin dehydration, and it is widely recognized as one of the most effective anti-aging cosmetic actives available today.
Accelerated Wound Healing
Sodium Hyaluronate is involved in all phases of wound repair — from initial inflammation and granulation tissue formation to re-epithelialization and matrix remodeling. Medical-grade preparations are used in wound dressings and post-surgical care.
Joint Health Support
Intra-articular injections and oral supplementation of Sodium Hyaluronate have been studied for their ability to improve joint lubrication, reduce pain, and slow cartilage degradation in conditions such as osteoarthritis.
Ophthalmic Comfort and Protection
Sodium Hyaluronate is a key active ingredient in ophthalmic solutions and eye drops for the relief of dry eye syndrome, ocular surface discomfort, and post-operative eye care. Its viscoelastic properties also make it indispensable as a surgical aid during cataract and corneal procedures.
Industry Applications
Sodium Hyaluronate Powder's versatility enables its use across a wide spectrum of commercial and therapeutic categories:
Cosmetics and Personal Care
- Anti-aging serums, moisturizers, and eye creams
- Hydrating face masks and sheet masks
- Lip care and body lotions
- Hair care products and scalp treatments
- Sunscreens and BB/CC creams
Dietary Supplements and Nutraceuticals
- Oral capsules and tablets for joint health and skin hydration
- Functional beverages and nutrition powders
- Beauty-from-within supplement formulations
Pharmaceutical and Medical Applications
- Ophthalmic solutions and artificial tear eye drops
- Intra-articular injections for osteoarthritis management
- Wound healing dressings and gels
- Surgical viscoelastic agents for ophthalmic procedures
- Nasal and mucosal delivery systems
Food and Beverage (Food Grade)
- Functional food ingredients
- Collagen and beauty drink formulations
- Nutraceutical blends for skin and joint support
Certificate of Analysis — Cosmetic Grade Sodium Hyaluronate Powder
The following Certificate of Analysis (COA) reflects a representative batch of our Cosmetic Grade Sodium Hyaluronate Powder, demonstrating compliance with stringent quality parameters:
| Test Item | Specification | Result |
|---|---|---|
| Appearance | White Powder | Complied |
| Glucuronic Acid | ≥ 44.5% | 48.20% |
| Hyaluronic Acid Purity | ≥ 98.0% | 99.30% |
| pH (0.5% aq. sol., 25°C) | 5.0 – 8.5 | 7.3 |
| Transmittance (T550nm, 0.5% aq. sol.) | ≥ 99.0% | 99.90% |
| Loss on Drying | ≤ 10.0% | 6.70% |
| Molecular Weight | Measured value | 1.60 × 10⁶ Da |
| Intrinsic Viscosity | Measured value | 17.5 dL/g |
| Kinematic Viscosity | Measured value | 36.6 mm²/s |
| Absorbance (A280nm, 0.5% aq. sol.) | ≤ 0.25 | 0.13 |
| Protein Content | ≤ 0.1% | 0.04% |
| Mercury (Hg) | ≤ 1.0 mg/kg | < 1.0 mg/kg |
| Lead (Pb) | ≤ 10.0 mg/kg | < 1.0 mg/kg |
| Arsenic (As) | ≤ 2.0 mg/kg | < 2.0 mg/kg |
| Cadmium (Cd) | ≤ 5.0 mg/kg | < 5.0 mg/kg |
| Total Bacterial Count | ≤ 100 CFU/g | Complied |
| Yeast & Mold | ≤ 50 CFU/g | Complied |
| Staphylococcus aureus | Negative | Negative |
| Pseudomonas aeruginosa | Negative | Negative |
| Thermotolerant Coliform Bacteria | Negative | Negative |
| Overall Conclusion | Qualified |
Full batch-specific COA documentation is available upon request. Our quality assurance team conducts in-process and finished product testing at every production stage to ensure lot-to-lot consistency.
Manufacturing Standards and Certifications
Extract Makers produces Sodium Hyaluronate Powder in a GMP-compliant manufacturing facility equipped with advanced fermentation, purification, and drying technology. Our production processes and quality management systems are certified under the following internationally recognized standards:
- GMP (Good Manufacturing Practice)
- ISO 9001 — Quality Management System
- ISO 22000 — Food Safety Management System
- HACCP — Hazard Analysis and Critical Control Points
- Kosher Certified
- Halal Certified
- FDA Registered Facility
These certifications affirm our commitment to producing raw materials that meet the regulatory and quality requirements of buyers in North America, Europe, Asia-Pacific, and other global markets. Documentation packages including COA, MSDS, TDS, and certification copies are readily available for customs clearance and regulatory submissions.
Production Process Overview
Our Sodium Hyaluronate Powder is produced through microbial fermentation using selected Streptococcus equi subspecies strains under controlled bioreactor conditions. The fermentation-derived hyaluronic acid undergoes multi-stage purification involving precipitation, filtration, and endotoxin removal to achieve pharmaceutical and cosmetic purity standards. The purified intermediate is then converted to its sodium salt form, spray-dried or lyophilized, and milled to the desired particle size distribution.
This biotechnology-based production route offers several advantages over traditional animal-derived hyaluronic acid, including:
- Freedom from animal-origin raw materials, supporting vegan and cruelty-free product positioning
- Reduced risk of zoonotic contamination
- Superior batch-to-batch consistency
- Scalable production capacity for large-volume orders
- Controllable molecular weight output to meet diverse specification requirements
Solubility, Stability, and Formulation Compatibility
Solubility: Sodium Hyaluronate Powder dissolves readily in water to form clear, viscous solutions. Dissolution is facilitated by gradual addition to water under moderate stirring. It is not soluble in alcohol, acetone, or other common organic solvents.
Stability: The powder form is stable under recommended storage conditions. In aqueous solution, stability is optimal at pH 5.0–8.5. Prolonged exposure to extreme heat, strong acids, or oxidizing agents may cause molecular weight degradation. Avoid high shear mixing during formulation to preserve viscosity.
Formulation Compatibility: Sodium Hyaluronate is compatible with most cosmetic and pharmaceutical excipients, including glycerin, niacinamide, peptides, vitamin C derivatives, and preservative systems. Its polyanionic nature may cause interactions with cationic polymers or high concentrations of certain cationic surfactants, which should be evaluated during formulation development.
Storage and Handling Recommendations
- Store in a tightly sealed container, protected from light and moisture
- Recommended storage temperature: 2°C – 10°C
- Keep away from heat sources and oxidizing agents
- Standard shelf life: 2 years from date of manufacture under recommended conditions
- Handle in low-humidity environments to prevent caking
Packaging Specifications
Extract Makers offers flexible packaging options to accommodate laboratory-scale testing through full commercial production orders:
- 1 kg – 5 kg: Double-sealed aluminum foil bags
- 10 kg – 20 kg: Corrugated cartons with double inner polyethylene liners (10 kg per carton)
- 10 kg – 30 kg: Fiber drums with inner moisture-barrier liners
Private Label and Custom Packaging
For distributors, brand owners, and retailers seeking to market finished or semi-finished products under their own brand, we offer comprehensive private label and custom packaging services. We can incorporate your logo, brand identity, label design, and product specifications onto packaging of your chosen format, enabling you to bring products to market efficiently without additional third-party packaging investment.
Free Samples Available
We understand that quality verification is a critical step in the sourcing decision. Extract Makers offers complimentary samples of 10g – 20g for qualified buyers to evaluate product quality, appearance, solubility, and performance before placing a bulk order. Sample requests for premium-grade or specialized molecular weight fractions may require confirmation of pricing arrangements prior to dispatch.
Shipping and Logistics
Extract Makers supports global distribution with flexible shipping arrangements:
- Orders below 1 metric ton: Available via DHL, FedEx, UPS, EMS, and other international express courier services
- Larger commercial orders: Sea freight (FCL/LCL) and railway shipping options available to most major destinations worldwide
All shipments are accompanied by complete documentation including commercial invoice, packing list, Certificate of Analysis, MSDS, and any required certificates of origin or phytosanitary documentation.
After-Sale Service and Quality Guarantee
Customer confidence is central to our business philosophy. Our after-sale service commitment includes:
- 2-year product guarantee from the manufacturing date under proper storage conditions
- Hassle-free return policy: In the event that a product batch does not meet the agreed specification, we will arrange a refund or replacement proportional to the quantity affected
- Dedicated technical support for formulation inquiries, regulatory documentation, and application guidance
Related Hyaluronic Acid Products
In addition to standard Sodium Hyaluronate Powder, Extract Makers also supplies a range of specialized hyaluronic acid derivatives and formats to support diverse application needs:
- Cross-Linked Hyaluronic Acid Powder — for dermal filler and advanced skin care applications
- Sodium Acetylated Hyaluronate Powder — enhanced lipophilicity for improved skin penetration
- Eye Drop Grade Hyaluronic Acid Powder — ultra-high purity for ophthalmic formulations
- Hyaluronic Acid Gel — ready-to-use gel format for topical and medical applications
Request a Quote or Free Sample
Extract Makers maintains an extensive inventory of Sodium Hyaluronate Powder across all major molecular weight grades and quality tiers. Whether you are a cosmetic formulator, nutraceutical brand, pharmaceutical manufacturer, contract research organization, or international distributor, we are equipped to meet your sourcing requirements with consistency, compliance, and competitive pricing.
To request a sample, obtain a product quotation, or discuss your specific requirements in detail, please contact our international sales team directly:
Email: [email protected]
We also supply more than 2,000 additional ingredient categories including plant extracts, botanical powders, amino acids, vitamins, minerals, and specialty food additives. If you do not find a specific product listed on our site, please reach out directly — our sourcing team can assist with custom procurement requests.
