Overview
L-Ergothioneine Powder is a high-value, naturally occurring amino acid derivative widely recognized for its exceptional antioxidant activity and cytoprotective properties. As demand for premium functional ingredients grows across nutraceuticals, cosmetics, and food fortification sectors, L-Ergothioneine has emerged as one of the most scientifically compelling bioactive compounds available in the bulk ingredient market today.
At Extract Makers, we supply L-Ergothioneine Powder in two distinct grades — natural mushroom-extracted and high-purity fermentation-derived — providing formulation flexibility for manufacturers, brand owners, and distributors worldwide.
Product Specifications at a Glance
| Parameter | Mushroom-Extracted | Fermentation-Derived |
|---|---|---|
| Source | Agaricus blazei (Royal Sun Mushroom) | Microbial Fermentation |
| Purity | 0.5%, 1% | ≥99% |
| Appearance | Brown Powder | White Crystalline Powder |
| CAS Number | 497-30-3 | 497-30-3 |
| Shelf Life | 24 Months | 24 Months |
Two Premium Sources of L-Ergothioneine
Mushroom-Extracted L-Ergothioneine (0.5% & 1%)
The mushroom-derived grade is sourced from Agaricus blazei, a species naturally abundant in L-Ergothioneine and long used in traditional wellness applications. Leveraging carefully controlled extraction protocols, this grade yields a standardized brown powder with consistent active content at either 0.5% or 1% potency.
This form is particularly well-suited for products that benefit from the synergistic phytonutrient profile of whole-mushroom matrices, including certain functional food products, traditional health supplements, and botanically positioned formulations.
Fermentation-Derived L-Ergothioneine (≥99% Purity)
The fermentation-derived grade represents the highest purity commercially available form of L-Ergothioneine. Produced through advanced biosynthetic fermentation using optimized microbial strains, this process yields a pure white crystalline powder with a confirmed purity of ≥99% by HPLC analysis.
This pharmaceutical and nutraceutical-grade material is ideal for precision formulations where dosing accuracy, ingredient purity, and regulatory compliance are paramount — including dietary supplements, clinical nutrition products, cosmetic actives, and specialty food ingredients.
Chemical & Physical Characteristics
- Chemical Name: L-(+)-Ergothioneine
- CAS Number: 497-30-3
- Molecular Formula: C₉H₁₅N₃O₂S
- Appearance: White crystalline powder (fermented) / Brown powder (mushroom-extracted)
- Solubility: Freely soluble in water; insoluble in most organic solvents
- Physical Form: Solid powder
- Stability: Stable under recommended storage conditions; antioxidant activity preserved when stored away from heat, moisture, and direct light
The high water solubility of L-Ergothioneine makes it an excellent candidate for aqueous-based formulations, including beverages, liquid supplements, serums, and effervescent products. Its stability profile also supports incorporation into solid dosage forms such as capsules, tablets, and sachets.
Bioactivity & Functional Benefits
L-Ergothioneine is a naturally occurring thiol-histidine betaine amino acid that the human body cannot synthesize on its own, making dietary and supplemental intake the only means of obtaining this compound. It is transported into cells via a highly specific transporter protein known as OCTN1 (ETT — Ergothioneine Transporter), which is expressed at notably high levels in tissues subject to significant oxidative burden, including the liver, kidneys, bone marrow, and brain.
Key Functional Properties
Cellular Antioxidant Protection
L-Ergothioneine functions as a powerful intracellular antioxidant, scavenging reactive oxygen species (ROS) and neutralizing free radicals before they can cause cellular damage. Research indicates that cells deficient in the ergothioneine transporter (ETT) are significantly more vulnerable to oxidative stress, exhibiting elevated mitochondrial DNA damage, increased protein oxidation, and heightened lipid peroxidation — all hallmarks of accelerated cellular aging and dysfunction.
Mitochondrial Support
Due to its selective accumulation in mitochondria — the primary site of oxidative metabolism — L-Ergothioneine provides targeted protection to the cell's energy-producing organelles, supporting overall metabolic function and cellular resilience.
Anti-Inflammatory Activity
Emerging research suggests L-Ergothioneine may modulate inflammatory signaling pathways, making it of growing interest in formulations targeting inflammatory conditions, metabolic health, and cognitive wellness.
Skin Protection & Cosmetic Applications
L-Ergothioneine is increasingly adopted in premium skincare and cosmetic formulations as a topically active antioxidant. It helps protect skin cells from UV-induced oxidative damage, supports skin barrier integrity, and contributes to visible anti-aging benefits — driving strong demand among cosmetic ingredient buyers and personal care brands.
Certificate of Analysis — Fermented L-Ergothioneine (99%)
| Test Item | Specification | Result | Test Method |
|---|---|---|---|
| Appearance | White Crystals | Conforms | Visual |
| Residue on Ignition | ≤2.0% | 0.09% | USP <281> |
| Loss on Drying | ≤0.5% | 0.08% | USP <731> |
| Ethanol Residue | ≤500 ppm | Conforms | GC |
| Purity | ≥99% | 99.22% | HPLC |
| Heavy Metals (Total) | ≤10 ppm | Conforms | ICP-MS |
| Lead (Pb) | ≤1 ppm | Conforms | ICP-MS |
| Arsenic (As) | ≤1 ppm | Conforms | ICP-MS |
| Cadmium (Cd) | ≤0.3 ppm | Conforms | ICP-MS |
| Mercury (Hg) | ≤0.1 ppm | Conforms | ICP-MS |
| Total Plate Count | ≤1,000 cfu/g | Conforms | USP <2021> |
| Total Yeast & Mold | ≤100 cfu/g | Conforms | USP <2021> |
| E. coli | Negative | Conforms | USP <2022> |
| Salmonella | Negative | Conforms | USP <2022> |
| Staphylococcus | Negative | Conforms | USP <2022> |
| Conclusion | Sample Qualified | — | — |
Quality Standards & Certifications
Extract Makers operates from a fully GMP-compliant manufacturing facility, with quality systems validated and certified to internationally recognized standards. Our production infrastructure and quality management framework support full batch traceability, in-process quality controls, and rigorous finished product testing before release.
Certifications held include:
- GMP (Good Manufacturing Practice)
- HACCP
- ISO 22000
- ISO 9001
- Kosher
- Halal
- FDA Registration
These certifications reflect our commitment to supplying ingredients that meet the regulatory and quality expectations of global markets, including North America, Europe, Asia-Pacific, and beyond. Whether you are a supplement brand, a cosmetic manufacturer, a food ingredient distributor, or a clinical nutrition company, our certification framework supports your compliance requirements.
Industry Applications
L-Ergothioneine Powder is a versatile active ingredient serving multiple high-growth market segments:
Dietary Supplements & Nutraceuticals
Capsules, softgels, tablets, and powdered blends targeting antioxidant support, healthy aging, cognitive health, immune function, and energy metabolism.
Functional Foods & Beverages
Incorporation into fortified beverages, nutrition bars, meal replacement products, and functional food systems where clean-label antioxidant enrichment is desired.
Cosmetics & Personal Care
Serums, moisturizers, eye creams, sunscreens, and anti-aging formulations leveraging L-Ergothioneine's demonstrated photoprotective and skin cell-protective properties.
Clinical & Medical Nutrition
Specialty formulas designed for populations with elevated oxidative stress, including products for aging adults, athletic recovery, or metabolic health management.
Animal Nutrition
Growing interest in ergothioneine supplementation for companion animal and livestock health applications, particularly in the area of oxidative stress management.
Storage & Stability Recommendations
To maintain product integrity and extend shelf life to the full 24-month period, L-Ergothioneine Powder should be stored under the following conditions:
- Temperature: Cool, controlled environment
- Humidity: Store away from moisture and high-humidity conditions
- Light: Protect from direct light exposure
- Container: Keep in original, sealed packaging until use
- Retest Interval: Every 24 months when stored under recommended conditions
Proper storage ensures that potency, purity, and physical characteristics remain within specification throughout the product's shelf life.
Packaging Options
Extract Makers offers flexible packaging configurations to accommodate orders of all volumes, from sample quantities to full commercial supply:
- 1 kg – 5 kg: Aluminum foil bags (heat-sealed, moisture-barrier)
- 10 kg – 20 kg: Double-lined carton packaging
- 10 kg – 30 kg: Fiber drums with inner liner
Private Label & Custom Packaging
For brand owners and distributors who require retail-ready packaging, we offer comprehensive private label services. We can produce custom-branded bags, pouches, or containers featuring your company logo, design, regulatory labeling, and barcode information. This end-to-end packaging solution eliminates the need for third-party packaging operations, reducing your lead time, labor costs, and supply chain complexity.
Shipping & Logistics
Extract Makers has extensive experience managing international bulk ingredient logistics, with established partnerships with leading global carriers and freight forwarders.
- Small to Mid-Volume Orders (below 1 metric ton): DHL, FedEx, UPS, EMS, and other express courier services
- Large-Volume Orders: Sea freight (FCL/LCL) or railway freight where applicable, providing cost-effective solutions for high-volume procurement
We provide full export documentation, including Certificate of Analysis, Certificate of Origin, MSDS/SDS, and customs invoices, to facilitate smooth customs clearance in your destination country.
Free Samples for Quality Evaluation
We understand that sourcing decisions require firsthand quality verification. Extract Makers provides complimentary product samples of 10g–20g of L-Ergothioneine Powder to qualified buyers. For high-value grades, sample availability and quantities are subject to confirmation based on current inventory.
We encourage procurement managers, R&D teams, and quality assurance professionals to request samples before placing bulk orders, ensuring full confidence in the material's suitability for your specific application.
After-Sales Support & Quality Guarantee
All L-Ergothioneine Powder supplied by Extract Makers is backed by a 24-month product guarantee from the date of manufacture, subject to proper storage conditions being maintained. Our after-sales support policy includes:
- Hassle-free return processing for non-conforming product
- Refunds processed in proportion to the quantity of returned goods
- Responsive technical support for formulation and application inquiries
- Dedicated account management for ongoing supply relationships
Why Source L-Ergothioneine Powder from Extract Makers?
- Dual-source availability: Both natural mushroom-extracted and high-purity fermented grades in stock
- Verified purity: 99.22% HPLC-confirmed purity on fermented grade
- Full certification portfolio: GMP, ISO, HACCP, Kosher, Halal, FDA-registered facility
- Flexible MOQs and packaging: Scalable from sample through full commercial volumes
- Private label capability: Custom packaging and branding services available
- Global logistics expertise: Reliable delivery to North America, Europe, Asia, and beyond
- Transparent quality documentation: Full CoA, SDS, and regulatory support documents provided
Contact Us
To request a quotation, product specifications, a Certificate of Analysis, or a free sample of L-Ergothioneine Powder, please reach out to our team directly:
📧 Email: [email protected]
Our technical and commercial team is available to assist manufacturers, formulators, importers, distributors, and brand owners with all product and procurement inquiries. We also supply over 2,000 plant extracts, nutritional ingredients, and specialty raw materials — if you are looking for a product not listed on our website, please contact us directly and we will do our best to accommodate your requirements.
